I am Kalaivani Raju, a Ph.D. student in the Indian Institute of Science (IISc.), Bangalore. My area of research can be broadly described as computational biology with special focus on protein biophysics and evolution.
For my doctoral dissertation, I asked several questions on the interrelationship between the function, dynamics and structure of protein kinases. I also identified the specificity conferring residues in 107 protein kinase families, which can potentially render modularity to the kinase superfamily. I submitted my doctoral thesis on "Dynamics of protein kinases: Its relationship to functional sites and states" in January 2017 and am awaiting thesis defense shortly.
At the undergraduate level, I was trained as an engineer in Biotechnology (Anna University, Chennai, India). After the 4-year programme, I took to full-time research as a Ph.D. student in IISc. Apart from protein biology, my interests and research experiences include theoretical and cognitive neuroscience.
- R. Kalaivani and N. Srinivasan, A Gaussian network model study suggests that structural fluctuations are higher for inactive states than active states of protein kinases, Mol. BioSyst., 2015, 11, 1079-1095, DOI: 10.1039/C4MB00675E. [Download]
- R. Kalaivani, A. G. de Brevern and N. Srinivasan, Conservation of structural fluctuations in homologous protein kinases and its implications on functional sites, Proteins, 2016, 84:7, 957–978, DOI: 10.1002/prot.25044 [Download]. Featured on journal cover [Download].
- R. Kalaivani, R. Reema and N. Srinivasan, Recognition of sites of functional specialisation in all known eukaryotic kinases.
- R. Kalaivani, T. N. Narwani, A. G. de Brevern and N. Srinivasan, Microsecond-range molecular dynamics simulations of diverse forms of PKA show that the inactive forms are more dynamic than active forms.
- R. Kalaivani, A. G. de Brevern and N. Srinivasan, Accidental finding of a novel PKA structural conformation.
- R. Kalaivani and N. Srinivasan, Frequency of substitution of structural fluctuations during the evolution of protein kinases.
- S. Chandra, R. Kalaivani, M. Kumar, N. Srinivasan and D.P. Sarkar, Villin-induced remodelling of actin cytoskeleton enhances Sendai virus-host cell fusion.
- R. Reema, R. Kalaivani and N. Srinivasan, Accommodation of rogue substrates in kinase fold.
Seefeld in Tirol, Austria
Awards and activities
to attend workshop on modularity of signalling proteins, Seefeld in Tirol, Austria
PLOS ONE science journal
to attend practical course on Biomolecular simulations, Pasteur Institute, Paris
Neuroscience, 2nd year undergraduate course, IISc.
Council of scientific and industrial research, India
Council of Scientific and Industrial Research – within top 100
2nd rank among all colleges under Anna University
All India Rank 4
One of the 50 selected participants from India
The following people may be contacted for reference.
Prof. N. Srinivasan
Dr. Alexandre G. de Brevern
French Institute for Health and Medical Research (INSERM)
Dynamique des Structures et Interactions des Macromolécules
University Paris Diderot, Sorbonne Paris Cite (UP7)
National Institute for Blood Transfusion (INTS)
Lab webpage, Personal page