I am a computational biologist, with over a decade of academic research in life sciences. Using computational tools, I have systematically assimilated and analysed data of varied structures. With strong background in statistical and analytical approaches, I am looking to transition to avenues of application.
I am currently pursuing computational transcriptomics with special focus on cell to cell transdifferentiation. My area of expertise can be broadly described as computational biology, through which I have tackled problems in a wide spectrum of areas including protein biophysics, cell biology, evolution and neuroscience.
For my doctoral dissertation, I asked several questions on the interrelationship between the function, dynamics and structure of protein kinases. I also identified the specificity conferring residues in all known protein kinase families, which can potentially render modularity to the kinase superfamily. I defended my doctoral thesis on "Dynamics of protein kinases: Its relationship to functional sites and states" in May 2017.
At the undergraduate level, I was trained as an engineer in Biotechnology. After the 4-year programme, I took to full-time research as a Ph.D. student.
- R. Kalaivani and N. Srinivasan, A Gaussian network model study suggests that structural fluctuations are higher for inactive states than active states of protein kinases, Mol. BioSyst., 2015, 11, 1079-1095, DOI: 10.1039/C4MB00675E. [Download]
- R. Kalaivani, A. G. de Brevern and N. Srinivasan, Conservation of structural fluctuations in homologous protein kinases and its implications on functional sites, Proteins, 2016, 84:7, 957–978, DOI: 10.1002/prot.25044 [Download]. Featured on journal cover [Download].
- S. Chandra, R. Kalaivani, M. Kumar, N. Srinivasan and D. P. Sarkar, Sendai virus recruits cellular villin to remodel actin cytoskeleton during fusion with hepatocytes, Molecular biology of the cell, 2017, 28:26, 3801-3814, DOI:10.1091/mbc.e17-06-0400. [Download].
- R. Kalaivani, R. Reema and N. Srinivasan, Recognition of sites of functional specialisation in all known eukaryotic protein kinase families, PLoS computational biology, 2018, 14:2, e1005975, DOI:10.1371/journal.pcbi.1005975. [Download].
- S. Wani, N. Maharshi, D. Kothiwal, L. Mahendrawada, R. Kalaivani and S. Laloraya, Interaction of the Saccharomyces cerevisiae RING-domain protein Nse1 with Nse3 and the Smc5/6 complex is required for chromosome replication and stability, Current genetics, 2018, 64:3, 599-617, DOI:10.1007/s00294-017-0776-6. [Download].
- R. Kalaivani, T. N. Narwani, A. G. de Brevern and N. Srinivasan, Microsecond-range molecular dynamics simulations of diverse forms of PKA show that the inactive forms are more dynamic than active forms.
- R. Kalaivani, A. G. de Brevern and N. Srinivasan, Accidental finding of a novel PKA structural conformation.
- R. Kalaivani and N. Srinivasan, Frequency of substitution of structural fluctuations during the evolution of protein kinases.
- R. Reema, R. Kalaivani and N. Srinivasan, Accommodation of rogue substrates in kinase fold.
Seefeld in Tirol, Austria
Awards and activities
3-year funding from UK research innovation (UKRI)
to attend workshop on modularity of signalling proteins, Seefeld in Tirol, Austria
PLoS ONE, Scientific reports
to attend practical course on Biomolecular simulations, Pasteur Institute, Paris
Neuroscience, 2nd year undergraduate course, IISc.
Council of scientific and industrial research, India
Council of Scientific and Industrial Research – within top 100
2nd rank among all colleges under Anna University
All India Rank 4
One of the 50 selected participants from India
The following people may be contacted for reference.
Prof. N. Srinivasan
Dr. Alexandre G. de Brevern
French Institute for Health and Medical Research (INSERM)
Dynamique des Structures et Interactions des Macromolécules
University Paris Diderot, Sorbonne Paris Cite (UP7)
National Institute for Blood Transfusion (INTS)
Lab webpage, Personal page